Prescribing Information
Patient Information


Clinical Pharmacology
Safety
Dosage and Administration


 





 

DOSAGE and ADMINISTRATION

  • BUPHENYL® is available in powder form for infants and young children and in tablets for children weighing >20 kg and adults. 

  • BUPHENYL® is an oral medication and should be taken by mouth, or by nasogastric or gastrostomy tube.

  • The usual daily dose of BUPHENYL Tablets and Powder is:
    • 450 – 600 mg/kg/day for patients <20 kg
    • 9.9 – 13.0 g/m2/day in patients >20 kg

  • BUPHENYL® should be taken in equally divided doses with each meal or feeding, three to six times per day.

  • The safety or efficacy of doses in excess of 20 grams (40 tablets) per day has not been established.

  • BUPHENYL® must be combined with dietary protein restriction and, in some cases, essential amino acid supplementation.

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